ACTEMRA PACKAGE INSERT PDF

Learn about ACTEMRA® treatment for rheumatoid arthritis, giant cell arteritis, systemic juvenile idiopathic arthritis, and polyarticular juvenile idiopathic arthritis. Find instructions for ACTEMRA® (tocilizumab) subcutaneous injections and helpful information on the ACTEMRA® Medication Guide that should help you better. Inside this kit you’ll also find: .. Some patients may be eligible for free drug through the .. Use a quick, dart-like motion to insert the needle all the way into.

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In PJIA patients, infusion-related reactions are defined as all events occurring during or within 24 hours of an infusion. Tell actemrz healthcare provider right away if you see any signs of these symptoms: Your healthcare provider should do blood tests to check your cholesterol levels knsert to 8 weeks aactemra you start receiving ACTEMRA, and then every 6 months after that You should not receive ACTEMRA if your neutrophil and platelet counts are too low or your liver function test levels are too high.

Reporting side effects Tell your healthcare pakcage right away if you are experiencing any side effects. The most common ISRs were erythema, pruritus, pain, and swelling at the injection site. Talking to your doctor Make the most of your office visit with this helpful guide. These ISRs occurred in a greater proportion of patients at or above 30 kg The impact of treatment with ACTEMRA on demyelinating disorders is not known, but multiple sclerosis and chronic inflammatory demyelinating polyneuropathy were reported rarely in clinical studies.

The purpose of this registry is to check the health of the pregnant mother and her baby.

An infection, think you may have an infection, are being treated for an infection, or get a lot of infections that return. Your email has been sent! Upper respiratory tract infections like common cold and sinus infections. Reviewing the Medication Guide should help you to better understand the risks and benefits of your RA treatment. ACTEMRA for intravenous use should only be infused psckage a healthcare professional with appropriate medical support to manage anaphylaxis.

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Increased blood pressure also called hypertension. Gastrointestinal Perforations Events of gastrointestinal GI perforation have been reported in clinical trials, primarily as complications of diverticulitis in RA patients. Members have access to online educational resources and treatment management tools. Shortness of breath or trouble breathing Swelling of lips, tongue, or face Chest pain Feeling dizzy or faint Moderate or severe abdominal pain or vomiting.

Sweating or chills Shortness of breath Warm, red or painful skin or sores on your body Feel very tired Muscle aches Blood in phlegm Diarrhea or packzge pain Cough Weight loss Burning when you urinate or urinating more often than normal Any of the following conditions that may give you a higher chance inxert getting infections.

Patients treated with ACTEMRA are at increased risk for developing serious infections that may lead to hospitalization or death, including tuberculosis TBbacterial, invasive fungal, viral, or other opportunistic infections. Invasive fungal infections, including candidiasis, aspergillosis, and pneumocystis. In patients who develop a platelet count less than 50, per mm 3treatment is not recommended.

To learn more, call or talk to your healthcare provider to register. Infections The rate of infections was Prescribers should exercise caution in considering the use of ACTEMRA in patients with preexisting or recent-onset demyelinating disorders.

Infection signs, with or without a fever, include sweating or chills; shortness of breath; warm, red or painful skin or sores on your body; feeling very tired; muscle aches; blood in phlegm; diarrhea or stomach acetmra cough; weight loss; burning when you urinate or urinating more often than normal Any of the following conditions that may give you a higher chance of getting infections.

You may also report side effects to Genentech at Serious allergic reactions Serious allergic reactions, including death, can happen with ACTEMRA infusions or injections, even if they did packkage occur with an earlier infusion or injection. This information does not take the place of talking with your healthcare provider about your medical condition or your treatment.

The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc. ACTEMRA is indicated for the treatment of active systemic juvenile idiopathic arthritis in patients 2 years of age and older.

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Cytochrome Ps in the liver are down-regulated by infection and inflammation stimuli including cytokines such as IL The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc.

These injection-site reactions were mild to moderate in severity. Neutrophils are white blood cells that help the body fight infection low platelet count.

Actemra® (tocilizumab)

If you have polyarticular juvenile idiopathic arthritis PJIA you will have blood tests done every 4 to 8 weeks during treatment. Increased frequency and magnitude of these elevations was observed when potentially hepatotoxic drugs e.

If you have systemic juvenile idiopathic arthritis SJIA you will have blood tests done every 2 to 4 weeks during treatment. Contact immediately, as well as your healthcare provider or nurse, if you experience any of these reactions:. Your healthcare provider may stop your ACTEMRA treatment for a period of time pacjage change your dose of medicine if needed because of changes in these blood test results.

Serious allergic reactions, including death, can happen with ACTEMRA infusions or injections, even if they did not occur with an earlier infusion or injection.

In the open-label extension over an average duration of 73 weeks of treatment, the overall rate of serious infections was Dosage modifications may be required. There was no clear relationship between decreases in neutrophils below 1 x 10 9 per Actemga and the occurrence of serious infections.

The chart below shows how often these tests will occur. These parts include the Ohio and Mississippi River Valleys and the Southwest Hepatitis B or have had hepatitis B Be sure to contact your healthcare provider or nurse if you see any signs of these side effects.

Subcutaneous Injections for RA | ACTEMRA® (tocilizumab)

Bacterial, viral and other infections due to opportunistic pathogens. Some people have died from these infections. The most common serious adverse reactions were serious infections.

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